VISDB Viral Integration Site DataBase

VIS ID

TVIS20000019

Fusion event

HPV-chr21:q22.3 integration

Validated

Yes

Detection method

PCR Ion Torrent Sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Chromosome

chr21

Cytoband

q22.3

Reference genome

Start

End

42078171/41784942 (Hg38)

Location type

Intronic

Target gene

PRDM15 ; RIPK4

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-587 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-4529-5p ; hsa-mir-4635 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-1827 ; hsa-mir-545-5p ; hsa-mir-5003-5p ; hsa-mir-4709-5p ; hsa-mir-5582-5p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an

Nearest miRNA

hsa-let-7c/Upstream/38101; hsa-mir-5692b/Downstream/1165986;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/6387, chr21-CpG: 16/Downstream/16513

Nearest cancer related gene

PRDM15(OG, No orient, 0)

Upstream sequence

aacaaaaaaacaagagaaaaaagaaaagaaaaacgaAATTCCCACAGCACTACATCTGCAGTAGGCACTGAAAGCCTCCTGTCCTGGGAGACTCCCCTCC

Downstream sequence

TGCCTCCTGGACAGTCCCACTCTGCCTTTGTCTCCCTTCTCTCCTCTTAGAATTCCCACTAGCCGGATGCCTCTGCCAACtgaagctactatgaacattg

Target sequence

tgcttattgcggcactattcacaatagcaaagacttggaaccaacccaaatgtccatcaatgatagactggattaagaaaatgtggcacatatacaccatggaatactatgcagtcataaaaaaggatgagttcatgtccgttgtagggacatggatgaagctggaaaccatcattctcagcaaactatcaca