Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20000021
Fusion event
HPV-MYC integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
End
128844999/127763571 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-let-7a-5p ; hsa-let-7g-5p ; hsa-mir-34a-5p ; hsa-mir-98-5p ; hsa-let-7c-5p ; hsa-mir-26a-5p ; hsa-mir-145-5p ; hsa-mir-21-5p ; hsa-mir-34b-5p ; hsa-mir-34c-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-34b-3p ; hsa-mir-378a-3p ; hsa-mir-371a-3p ; hsa-mir-373-3p ; hsa-mir-451a ; hsa-mir-33b-5p ; hsa-mir-135a-5p ; hsa-mir-449c-5p ; hsa-mir-429 ; hsa-mir-335-5p ; hsa-let-7f-5p ; hsa-mir-320b ; hsa-mir-744-5p ; hsa-mir-423-5p ; hsa-mir-320a ; hsa-let-7b-5p ; hsa-mir-148a-3p ; hsa-mir-212-3p ; hsa-mir-494-3p ; hsa-mir-155-5p ; hsa-mir-33a-5p ; hsa-mir-1294 ; hsa-mir-30a-3p ; hsa-mir-30d-3p ; hsa-mir-30e-3p ; hsa-mir-323a-3p ; hsa-mir-449a ; hsa-mir-940 ; hsa-mir-1304-5p ; hsa-mir-1827 ; hsa-mir-2682-5p ; hsa-mir-548au-3p ; hsa-mir-8074 ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4289 ; hsa-mir-16-2-3p ; hsa-mir-195-3p ; hsa-mir-5197-5p ; hsa-mir-6507-3p ; hsa-mir-487b-3p ; hsa-mir-7-5p ; hsa-mir-93-5p ; hsa-mir-324-3p ; hsa-mir-184 ; hsa-mir-126-5p ; hsa-mir-25-3p ; hsa-mir-92a-2-5p ; hsa-mir-92a-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-3p ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-516a-5p ; hsa-mir-455-3p ; hsa-mir-4677-3p ; hsa-mir-4510 ; hsa-mir-375 ; hsa-mir-3159 ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-23a-3p ; hsa-mir-222-3p ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-16-5p ; hsa-mir-151a-5p ; hsa-mir-148a-5p ; hsa-mir-125a-3p ; hsa-mir-125a-5p ; hsa-mir-1248 ; hsa-let-7i-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-mir-302a-5p ; hsa-mir-3919 ; hsa-mir-4699-3p ; hsa-mir-4797-5p ; hsa-mir-6765-5p ; hsa-mir-622 ; hsa-mir-135b-5p ; hsa-mir-889-5p ; hsa-mir-4668-5p ; hsa-mir-4762-5p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-130a-3p ; hsa-mir-25-5p ; hsa-mir-185-5p ; hsa-mir-29a-3p ; hsa-mir-561-3p ; hsa-mir-34a-3p ; hsa-mir-599 ; hsa-mir-29b-3p ; hsa-mir-129-2-3p ; hsa-mir-3157-5p ; hsa-mir-377-5p ; hsa-mir-4316 ; hsa-mir-4432 ; hsa-mir-4691-3p ; hsa-mir-512-5p ; hsa-mir-513c-5p ; hsa-mir-514b-5p ; hsa-mir-586 ; hsa-mir-6086 ; hsa-mir-655-5p
Nearest miRNA
hsa-mir-12123/Upstream/2941513; hsa-mir-10400/Downstream/32391;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24538, chr8-CpG: 94/Downstream/30264
Nearest cancer related gene
MYC(OG, No orient, 0)
Upstream sequence
AGATCCAGCGAATTATTCAGAATATTGGTTCTGCTTCGGATGAGATGCCAGTGAGAATATCACCAGCTAACTGCAGGCAGGGAGGAAGTCAATGGTAATT
Downstream sequence
AAACTTTGTTTCCTTGTACACAGCAGCCAACCGCAAGGTACACAGGAAATACACAGGCAGAAGTTGCCAAGAGCAACTGCAGATGAAAACTAGTAATAAA
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.