Basic Information
VIS ID
TVIS20000026
Fusion event
HPV-chr19:q13.2 integration
Validated
Yes
Detection method
PCR Ion Torrent Sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26660085
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
NCBI36/hg18
Start
45789652/40591906 (Hg38)
End
45789652/40591906 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LTBP4 ; SHKBP1 ; SPTBN4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-1304-5p ; hsa-mir-15a-3p ; hsa-mir-1827 ; hsa-mir-1972 ; hsa-mir-198 ; hsa-mir-219b-5p ; hsa-mir-3621 ; hsa-mir-3656 ; hsa-mir-3937 ; hsa-mir-4533 ; hsa-mir-4645-5p ; hsa-mir-4673 ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-4781-5p ; hsa-mir-505-3p ; hsa-mir-505-5p ; hsa-mir-523-3p ; hsa-mir-6125 ; hsa-mir-6765-5p ; hsa-mir-6777-5p ; hsa-mir-6825-5p ; hsa-mir-6889-5p
Nearest miRNA
hsa-mir-10395/Upstream/221999; hsa-let-7e/Downstream/1277721;
Nearest TSS
ENST00000633603/Upstream/1697; ENST00000593738/Downstream/977;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/14457, chr19-CpG: 31/Downstream/5033
Upstream sequence
aaaaaGGTGTTGCAGGGGAGGAATGTGTTGGCTTTTACTctgccttcaggcatggctggatccggggcttcaaacactaattcagaatatctttttttct
Downstream sequence
tttttcttttcttttttaaagtctcactctgtcatccaggctggagtgtagtggtatgatctcagctcactgcaacctccacctcccgggttcaagcaat
Reference
Bodelon, C., et al. Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis.2016, 37(2): 188-196.
Curate