VISDB Viral Integration Site DataBase

VIS ID

TVIS20000029

Fusion event

HPV-CACNG7 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Gene

L2

Start

5190

Integrated sequence

AGGTAGGTCGTGGTCAGCCATTAGGTGTGGGCATTAGTGGCCATCCTTTATTAAATAAATTGGATGACACAGAAAATGCTAGTGCTTATGCAGCAAATGC| |AGGTGTGGATAATAGAGAATGTATATCTATGGATTACAAACAAACACAATTGTGTTTAATTGGTTGCAAACCACCTATAGGGGAACACTGGGGCAAAGGA

Chromosome

chr19

Cytoband

q13.42

Reference genome

Start

End

54417038/53913784 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-3682-3p ; hsa-mir-1272 ; hsa-mir-580-5p ; hsa-mir-224-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7-5p ; hsa-mir-4786-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p

Nearest miRNA

hsa-let-7e/Upstream/125011; hsa-mir-10394/Downstream/68523;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/3951, chr19-CpG: 45/Downstream/28193

Upstream sequence

tgattattttaaattaaaggcacttagagatccatagatgctggaagaggctttcctcctatgtcttcttatctgcctaaagatcaaaaagaacacaagt

Downstream sequence

taaaaaaaaaaaaaaaaaaaaaaagaaaaTCTATACCTCCCAGGGACCACAAAGACCAATTCATTGTAAGAATCCTGGCTCCCCAGACCTCGTCCTCTTT