Basic Information
VIS ID
TVIS20000031
Fusion event
HPV-chr13:q22.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
3781
Integrated sequence
TCTATAGTTTCTTTAGTGGAAGAAACTAGTTTTATTGATGCTGGTGCACCAACATCTGTACCTTCCATTCCCCCAGATGTATCAGGATTTAGTATTACTA| |CTTCAACTGATACCACACCTGCTATATTAGATATTAATAATACTGTTACTACTGTTACTACACATAATAATCCCACTTTCACTGACCCATCTGTATTGCA
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
73996849/73422712 (Hg38)
End
73996849/73422712 (Hg38)
Fragile sites / regions
FRA13E
Nearest miRNA
hsa-mir-1297/Upstream/7204388; hsa-mir-1267/Downstream/4275300;
Nearest TSS
ENST00000623511/Upstream/347697; ENST00000430033/Downstream/124129;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/362480, chr13-CpG: 31/Downstream/711260
Upstream sequence
CCTGCTCCTGCTTCCTAGGCTGCTTTACTCCCCTGCTCAGTGTTACCTGTTATCATTTGCTGGACCGCTCCAGTACCACCTGCTTACCTGAATTTCTTAT
Downstream sequence
gtccagggctgcactttgagaaGATCTGTTCTACACAGATCTTGATAGGAAGAAGGCTATGTTGTAAAGGTTATCTAAGATGGGAAAGGGGAAATGGAGA
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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