Basic Information
VIS ID
TVIS20000032
Fusion event
HPV-chr7:p21.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
2849
Integrated sequence
CCCATAGTACATTTAAAAGGTGATGCTAATACTTTAAAATGTTTAAGATATAGATTTAAAAAGCATTGTACATTGTATACTGCAGTGTCGTCTACATGGC| |ATTGGACAGGACATAATGTAAAACATAAAAGTGCAATTGTTACACTTACATATGATAGTGAATGGCAACGTGACCAATTTTTGTCTCAAGTTAAAATACC
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
17799430/17759806 (Hg38)
End
17799430/17759806 (Hg38)
Nearest miRNA
hsa-mir-339/Upstream/10692761; hsa-mir-10399/Downstream/367414;
Nearest TSS
ENST00000635602/Upstream/80257; ENST00000455069/Downstream/61891;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/460329, chr7-CpG: 82/Downstream/180345
Upstream sequence
gactgctggtttacacgacccactttgtgatactttgttacagcagccctagcaaactaatacaCTCCACTGAGCTAGTTCCAAGAAAGAAAGAACAAAA
Downstream sequence
ccagctacttgggtgagtggtgggaggattggtcgagcccggaaggttgacgctgcaaagagccatgatgaccccactgcactccaggctgggtgataga
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
Curate