Basic Information
VIS ID
TVIS20000036
Fusion event
HPV-chr4:q13.3 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E1
Start
1063
Integrated sequence
TATAAAACAGGTATATCAAATATTAGTGAAGTGTATGGAGACACGCCAGAATGGATACAAAGACAAACAGTATTACAACATAGTTTTAATGATTGTACAT| |TTGAATTATCACAGATGGTACAATGGGCCTACGATAATGACATAGTAGACGATAGTGAAATTGCATATAAATATGCACAATTGGCAGACACTAATAGTAA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74594785/73729068 (Hg38)
End
74594785/73729068 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/7452140; hsa-mir-1243/Downstream/2844500;
Nearest TSS
ENST00000502981/Upstream/18766; ENST00000483500/Downstream/11438;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/108527, chr4-CpG: 19/Downstream/107635
Upstream sequence
aaccatattctactctctatctccatgagttcaaccgttttaatttttagctcctacaaatgggtgagaacatgtgaagtttgtctttctgtgcctggtg
Downstream sequence
ATCAAGTCCTCTTGATCCTAACACTGTAAATGGAAGAAGAAACAGGTTTGTTTTAACCTGGGAGGTGTAATTTCTTTCTTTCTTTCTttttttttttttt
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
Curate