Basic Information
VIS ID
TVIS20000037
Fusion event
HPV-chr10:q26.13 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E1
Start
2689
Integrated sequence
AACACAGACGACTATCCAGCGACCAAGATCAGAGCCAGACACCGGAAACCCCTGCCACACCACTAAGTTGTTGCACAGAGACTCAGTGGACAGTGCTCCA| |ATCCTCACTGCATTTAACAGCTCACACAAAGGACGGATTAACTGTAATAGTAACACTACACCCATAGTACATTTAAAAGGTGATGCTAATACTTTAAAAT
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
123715736/121956221 (Hg38)
End
123715736/121956221 (Hg38)
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1997629; hsa-mir-202/Downstream/460744;
Nearest TSS
ENST00000439456/Upstream/27420; ENST00000618971/Downstream/561;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/27627, chr10-CpG: 70/Downstream/18291
Nearby gene
ATE1-AS1(-4256) ; NSMCE4A(+867) ;
Upstream sequence
AAatggatgggtgggtggatggatggatggacagatgATACCATCAAAAGACAGAATGAATCTCTCACTGCATAGCAAAATTGGTTTTAAATAGCCCAAG
Downstream sequence
ACTTACCTAAGTACTAAATGTTATAAAACCAAACTCTTCTGACCTCTCAATCTAGTCAACTGGGGCTGTAATTATTAATGAAATTAATGTTTATTTTGAA
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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