Basic Information
VIS ID
TVIS20000039
Fusion event
HPV-chr20:q11.22 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E7
Start
850
Integrated sequence
ATAAAAACACTATTACAACAATATTGTTTATATTTACACATTCAAAGTTTAGCATGTTCATGGGGAATGGTTGTGTTACTATTAGTAAGATATAAATGTG| |GAAAAAATAGAGAAACAATTGAAAAATTGCTGTCTAAACTATTATGTGTGTCTCCAATGTGTATGATGATAGAGCCTCCAAAATTGCGTAGTACAGCAGC
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
32515477/33927671 (Hg38)
End
32515477/33927671 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/1689824; hsa-mir-1-1/Downstream/121448;
Nearest TSS
ENST00000382410/Upstream/116367; ENST00000413297/Downstream/64147;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/64712, chr20-CpG: 132/Downstream/65322
Upstream sequence
GCCTCGCAGCCTGTTTAGCACTAAGCGCACTTGGTTTATCTGGTCTGCGATCATGTCCGGAACACAGGGTCTTCTGTGTCCAAAGAACTTGACACACATA
Downstream sequence
agagcggggacccaaaccccagtgatgtgaaagccagagccaggctctgtctgTGGGTCTGGCAGCTGCCACATTTATTAGCTCCCTGATATCTCCTTGT
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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