Basic Information
VIS ID
TVIS20000041
Fusion event
HPV-TUBB8P12 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E1
Start
1277
Integrated sequence
TAAAAAGTAATTCACAGGCAAAAATTGTAAAGGATTGTGCAACAATGTGTAGACATTATAAACGAGCAGAAAAAAAACAAATGAGTATGAGTCAATGGAT| |AAAATATAGATGTGATAGGGTAGATGATGGAGGTGATTGGAAGCAAATTGTTATGTTTTTAAGGTATCAAGGTGTAGAGTTTATGTCATTTTTAACTGCA
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
50054/50054 (Hg38)
End
50054/50054 (Hg38)
Location type
Intronic
Target gene
TUBB8P12
Nearest miRNA
hsa-mir-1-2/Downstream/62202;
Nearest TSS
ENST00000575820/Upstream/497; ENST00000580410/Downstream/23463;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/399, chr18-CpG: 51/Downstream/23008
Upstream sequence
ttccttggctactctcttccctcataatcacatggtactctccctgtgtgtatgtctccctctactcaaatttcttttttttataaggacatcagtcata
Downstream sequence
tcaaacccgcagtaagctatgggtgttggagatagtcaggcgtctgatttagctggagtcttctgtagagtaggattagccctttcacctttccagagga
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
Curate