Basic Information
VIS ID
TVIS20000042
Fusion event
HPV-chr6:p24.3 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E1
Start
2623
Integrated sequence
TAGGCAGCACTTGGCCAACCACCCCGCCGCGACCCATACCAAAGCCGTCGCCTTGGGCACCGAAGAAACACAGACGACTATCCAGCGACCAAGATCAGAG| |CCAGACACCGGAAACCCCTGCCACACCACTAAGTTGTTGCACAGAGACTCAGTGGACAGTGCTCCAATCCTCACTGCATTTAACAGCTCACACAAAGGAC
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
8814272/8814039 (Hg38)
End
8814272/8814039 (Hg38)
Nearest miRNA
hsa-mir-3691/Upstream/2644604; hsa-mir-10398/Downstream/1625678;
Nearest TSS
ENST00000381078/Upstream/378428; ENST00000645232/Downstream/347738;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/378131, chr6-CpG: 41/Downstream/584821
Upstream sequence
TCATATAACTTAGATTCTTAAACATTTTGACTTTAAAGACTTTCTTTGTgacctagtacctggagcaggagtgaggtaaggtaatatttgaaacttgaat
Downstream sequence
ACCCAGCTCTGTCTCACAGCCACGTGAGAGTGCTCACTTCCCTTGGAGAGTGTGAGCTCTTTGAAAGAGGGAGGTTCAATAAGTGCTTTTCAGATTAAAT
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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