VISDB Viral Integration Site DataBase

VIS ID

TVIS20000043

Fusion event

HPV-ASXL1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E1

Start

2724

Integrated sequence

CAGACACCGGAAACCCCTGCCACACCACTAAGTTGTTGCACAGAGACTCAGTGGACAGTGCTCCAATCCTCACTGCATTTAACAGCTCACACAAAGGACG| |GATTAACTGTAATAGTAACACTACACCCATAGTACATTTAAAAGGTGATGCTAATACTTTAAAATGTTTAAGATATAGATTTAAAAAGCATTGTACATTG

Chromosome

chr20

Cytoband

q11.21

Reference genome

Start

End

30948621/32360818 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-6077 ; hsa-mir-7150 ; hsa-mir-6835-5p ; hsa-mir-3190-3p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-6849-5p ; hsa-mir-4270 ; hsa-mir-3681-5p ; hsa-mir-6732-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-4463 ; hsa-mir-7-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/122971; hsa-mir-1-1/Downstream/1688301;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/1588, chr20-CpG: 22/Downstream/95319

Nearest cancer related gene

ASXL1(TSG, No orient, 0)

Upstream sequence

AGTAACCTCCCACCTCTGTGAATGTCACTGCGGCATGGAGGGAGGAGGGAGTTGCCACTGGGGAGCCAGGGGCCTCCAGCCAAAGGACAGTGTGCGGTTC

Downstream sequence

TCTTTTTCTTCTAAGGCTCTTCATTAAAAATAGTAATATGAATAGGAATTACtttgtttgtttgtttttcgtttgtttgccaccacacccggctaatttt