Basic Information
VIS ID
TVIS20000045
Fusion event
HPV-chr6:p24.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
2891
Integrated sequence
TTAAGATATAGATTTAAAAAGCATTGTACATTGTATACTGCAGTGTCGTCTACATGGCATTGGACAGGACATAATGTAAAACATAAAAGTGCAATTGTTA| |CACTTACATATGATAGTGAATGGCAACGTGACCAATTTTTGTCTCAAGTTAAAATACCAAAAACTATTACAGTGTCTACTGGATTTATGTCTATATGACA
Host Sequence
Chromosome
chr6
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
12645768/12645536 (Hg38)
End
12645768/12645536 (Hg38)
Nearest miRNA
hsa-mir-3691/Upstream/2205742; hsa-mir-10398/Downstream/3496020;
Nearest TSS
ENST00000381078/Upstream/60132; ENST00000379348/Downstream/71269;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/632702, chr6-CpG: 44/Downstream/104109
Upstream sequence
ATAACTGGAATTTTGGGAGACAAAGAACTACTCCAAATGTTGGGAAACAGGCCTTCCTGTGGGGTTTGTTCTTTAGCATGGAAGCAACAGGAGCATCTAA
Downstream sequence
tttgcttgctgcctcttgtatccctgccatcaacataagaacatgcccactgatacggtttggctctgtgtccacactcaaatttcatgttgaattgtga
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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