Basic Information
VIS ID
TVIS20000052
Fusion event
HPV-KIAA1211L integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
L2
Start
4405
Integrated sequence
CTACGTACTCGTAGTGGAAAATCTATAGGTGCTAAGGTACATTATTATTATGATTTAAGTACTATTGATCCTGCAGAAGAAATAGAATTACAAACTATAA| |CACCTTCTACATATACTACCACTTCACATGCAGCCTCACCTACTTCTATTAATAATGGATTATATGATATTTATGCAGATGACTTTATTACAGATACTTC
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99438640/98822177 (Hg38)
End
99438640/98822177 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
KIAA1211L
Nearest miRNA
hsa-mir-1285-2/Upstream/2023824; hsa-mir-10b/Downstream/2487273;
Nearest TSS
ENST00000437798/Upstream/49257; ENST00000496794/Downstream/127;
Nearest CpG islands
chr2-CpG: 194/Target, None/Upstream, None/Downstream
Upstream sequence
TCCTGAACATCGGTCACTTGCATCTGGGATGGTTTGTCAATTTCTACAAATAAAAGCAGGGAGAAACCAGTGAAGCCCCAGTCCTTGGAGACAAGATTGG
Downstream sequence
CGCCATCCCTGTATTTGAGCGAGAGGGAGGTGGACCGGAGCTTGACGGGGAAGGGGTTTCTGTCCTCACTCGGGGCCGGCTCCTGGGCGGCTGGGCAGGG
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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