Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20000061
Fusion event
HPV-IGF1R integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Region type
E1
Start
1558
Integrated sequence
GGTATGAGTTTAATGAAATTTCTGCAAGGGTCTGTAATATGTTTTGTAAATTCTAAAAGCCATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTA| |TGTTAGATGATGCTACAGTGCCCTGTTGGAACTACATAGATGACAATTTAAGAAATGCATTGGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGACC
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
Start
End
99425642/98882413 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-133b ; hsa-mir-145-5p ; hsa-mir-7-5p ; hsa-mir-138-5p ; hsa-mir-194-5p ; hsa-mir-99a-5p ; hsa-mir-223-3p ; hsa-mir-100-5p ; hsa-mir-497-5p ; hsa-mir-152-3p ; hsa-mir-139-5p ; hsa-mir-376c-3p ; hsa-mir-376a-3p ; hsa-mir-181b-5p ; hsa-mir-383-5p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-183-5p ; hsa-mir-182-5p ; hsa-mir-196a-5p ; hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-let-7d-5p ; hsa-mir-1226-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-34a-5p ; hsa-mir-92a-3p ; hsa-let-7e-5p ; hsa-mir-125b-2-3p ; hsa-let-7c-5p ; hsa-mir-16-5p ; hsa-mir-630 ; hsa-let-7b-5p ; hsa-mir-143-3p ; hsa-mir-133a-3p ; hsa-mir-140-5p ; hsa-mir-150-3p ; hsa-mir-375 ; hsa-mir-511-3p ; hsa-mir-548n ; hsa-mir-548t-5p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-548at-5p ; hsa-mir-548az-5p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-503-5p ; hsa-mir-4670-3p ; hsa-mir-583 ; hsa-mir-885-5p ; hsa-mir-4668-5p ; hsa-mir-6124 ; hsa-mir-7151-5p ; hsa-let-7a-5p ; hsa-let-7f-5p ; hsa-mir-33a-3p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-577 ; hsa-mir-1294 ; hsa-mir-3927-3p ; hsa-mir-3935 ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-5586-3p ; hsa-mir-6740-5p ; hsa-mir-6831-5p ; hsa-mir-1275 ; hsa-mir-4665-5p ; hsa-mir-3919 ; hsa-mir-8485 ; hsa-mir-625-5p ; hsa-mir-3148 ; hsa-mir-4641 ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-1253 ; hsa-mir-302e ; hsa-mir-4299 ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-6770-5p ; hsa-mir-7855-5p ; hsa-mir-99b-5p ; hsa-mir-378a-3p ; hsa-mir-224-3p ; hsa-mir-522-3p ; hsa-mir-1468-3p ; hsa-mir-885-3p ; hsa-mir-3613-3p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-548d-3p ; hsa-mir-548h-3p ; hsa-mir-548z ; hsa-mir-548ac ; hsa-mir-548as-3p ; hsa-mir-548bb-3p ; hsa-mir-5681a ; hsa-mir-34a-3p ; hsa-mir-539-5p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-3617-3p ; hsa-mir-6511a-5p ; hsa-mir-8060 ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-6859-5p ; hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-520a-5p ; hsa-mir-525-5p ; hsa-mir-2467-3p ; hsa-mir-185-5p ; hsa-mir-206 ; hsa-mir-21-5p ; hsa-mir-26b-5p ; hsa-mir-486-5p ; hsa-mir-218-5p ; hsa-mir-4535 ; hsa-mir-4800-5p ; hsa-mir-8071 ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-8085 ; hsa-mir-3175 ; hsa-mir-6731-5p ; hsa-mir-659-5p ; hsa-mir-492 ; hsa-mir-6861-3p ; hsa-mir-6804-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-7109-5p ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-202-3p ; hsa-mir-3163 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-340-5p ; hsa-mir-4539 ; hsa-mir-3200-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-3191-5p ; hsa-mir-6873-3p ; hsa-mir-7978 ; hsa-mir-494-3p ; hsa-mir-4456 ; hsa-mir-548q ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-518c-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-4423-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-675-3p ; hsa-mir-223-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-4655-5p ; hsa-mir-224-5p ; hsa-mir-502-5p ; hsa-mir-3941 ; hsa-mir-3124-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-4433b-5p ; hsa-mir-203a-3p ; hsa-mir-6794-3p ; hsa-mir-377-3p ; hsa-mir-4433a-5p ; hsa-mir-342-3p ; hsa-mir-6884-3p ; hsa-mir-4639-3p ; hsa-mir-4511 ; hsa-mir-629-3p ; hsa-mir-3180-5p ; hsa-mir-488-5p ; hsa-mir-7161-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-570-3p ; hsa-mir-125b-1-3p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-6727-5p ; hsa-mir-6084 ; hsa-mir-6762-3p ; hsa-mir-4755-3p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4508 ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-10b-3p ; hsa-mir-6867-5p ; hsa-mir-5003-5p ; hsa-mir-15b-3p ; hsa-mir-7-1-3p ; hsa-mir-125b-5p ; hsa-mir-141-3p ; hsa-mir-214-5p ; hsa-mir-448 ; hsa-mir-217
Nearest miRNA
hsa-mir-10393/Upstream/97911; hsa-mir-1302-10/Downstream/3078046;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/29666, chr15-CpG: 30/Downstream/8923
Nearest cancer related gene
IGF1R(OG, No orient, 0)
Upstream sequence
ccattgctgcatttcctttgctatgaagtgagttccttggtcagaagcgatgttgtttggaatactatgatagtggttaaggcattttgtgattttacag
Downstream sequence
TGAAGAGTCACCCAGGTTTTTGTAAAGAAGTGTTTCAGATCAGTATGCAATGGATGACTGTAAATTTCTCTTCAGATCTAAGAATCTGTGATTGGATGAA
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.