Basic Information
VIS ID
TVIS20000063
Fusion event
HPV-chr21:p11.2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
L2
Start
4911
Integrated sequence
TGCCTCCTGTCCCAGTATCTAAGGTTGTAAGCACGGATGAATATGTTGCACGCACAAACATATATTATCATGCAGGAACATCCAGACTACTTGCAGTTGG| |ACATCCCTATTTTCCTATTAAAAAACCTAACAATAACAAAATATTAGTTCCTAAAGTATCAGGATTACAATACAGGGTATTTAGAATACATTTACCTGAC
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
10702626/10809829 (Hg38)
End
10702626/10809829 (Hg38)
Nearest miRNA
hsa-mir-10396a/Upstream/1822164; hsa-let-7c/Downstream/2596555;
Nearest TSS
ENST00000624081/Upstream/159994; ENST00000624445/Downstream/2206863;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/182105, chr21-CpG: 39/Downstream/2799786
Upstream sequence
ttctttgagatgtgtgctttcatctcacagagttaaaactttcttttgattcagcagtttggaaacactctttttgtgatatctgtaaatggatattagg
Downstream sequence
agtgctttgaggtcaatggtgacaaaggaaatatcctcacataaaaactaaacagaaattttctgagaaattactttttgatgtgtccattaatctaaca
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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