DENND5A _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20000064
Fusion event
HPV-DENND5A integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
LCR
Start
7
Integrated sequence
ATGGCTG| |ATCCTGCAGGTACCAATGGGGAAGAGGGTACGGGATGTAATGGATGGTTTTATGTAGAGGCTGTAGTGGAAAAAAAAACAGGGGATGCTATATCAGATGA
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
9283840/9262293 (Hg38)
End
9283840/9262293 (Hg38)
Location type
Intronic
Target gene
DENND5A
miRNAs that regulate target gene
hsa-mir-30d-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-210/Upstream/171914; hsa-let-7a-2/Downstream/1245977;
Nearest TSS
ENST00000527297/Upstream/55575; ENST00000630083/Downstream/2794;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/170478, chr11-CpG: 113/Downstream/2433
Upstream sequence
gtgtgggaatggttgcatggaggatggccagggccacccatcccctaaagctcaccatgcccctcttggtggttttggtctttggtgactgtgtgatctt
Downstream sequence
CTTTTGGAACATAAATTCTTTACATCAGGCTTTGTGCTAGAAATAGCTATTTGCAATGCTTTTTCCAGAATTTTTAATGAGTGTATCTCTAGTTTCTTTT
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
Curate