Basic Information
VIS ID
TVIS20000074
Fusion event
HPV-chr8:q24.21 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Gene
E2
Start
3644
Integrated sequence
TAGGAATTGGAACAGGGTCGGGTACAGGCGGACGCACTGGGTATATTCCATTGGGAACAAGGCCTCCCACAGCTACAGATACACTTGCTCCTGTAAGACC| |CCCTTTAACAGTAGATCCTGTGGGCCCTTCTGATCCTTCTATAGTTTCTTTAGTGGAAGAAACTAGTTTTATTGATGCTGGTGCACCAACATCTGTACCT
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128596370/127584125 (Hg38)
End
128596370/127584125 (Hg38)
Nearest miRNA
hsa-mir-12123/Upstream/2762067; hsa-mir-10400/Downstream/211837;
Nearest TSS
ENST00000518652/Upstream/101986; ENST00000641252/Downstream/149842;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/268232, chr8-CpG: 17/Downstream/149879
Upstream sequence
TGTATCTTGAGTAAAACGTTTTGATTAAATAGAAGCAGTTTTCCTTTATTCTCAATAAATGTTTTCCTCTAAGAAAGGTAAAATGATTTAAACATGAGCT
Downstream sequence
ATTTTCCATCTTTTTACCCTTCCATTAGCAGTTTGCAAACACTGCTATTGCAATTCTCCTCCCCGAtgtattattccattctcacgttgttataaagaac
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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