VISDB Viral Integration Site DataBase

VIS ID

TVIS20000075

Fusion event

HPV-SWAP70 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E2

Start

3742

Integrated sequence

CCCCCTTTAACAGTAGATCCTGTGGGCCCTTCTGATCCTTCTATAGTTTCTTTAGTGGAAGAAACTAGTTTTATTGATGCTGGTGCACCAACATCTGTAC| |CTTCCATTCCCCCAGATGTATCAGGATTTAGTATTACTACTTCAACTGATACCACACCTGCTATATTAGATATTAATAATACTGTTACTACTGTTACTAC

Chromosome

chr11

Cytoband

p15.4

Reference genome

Start

End

9697576/9676029 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-145-5p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p ; hsa-mir-4637 ; hsa-mir-4445-5p ; hsa-mir-186-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a

Nearest miRNA

hsa-mir-210/Upstream/585650; hsa-let-7a-2/Downstream/832241;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/11526, chr11-CpG: 72/Downstream/82188

Nearest cancer related gene

SWAP70(OG, No orient, 0)

Upstream sequence

CGGCCCTGCAGCCAGCTCACGTCCAGGTTCAACCCACAGCTACTTGGTTTGTGTTCTTCTTCATATTCTAAAACCATTCCATTTCCAAGCACTTTCAGTC

Downstream sequence

ACAGCAGAGTCAGGTTCTGAGGTTGGGCCACCGAGGTTACTGACGCCTTCCTGCTCTGGTTAAGACGTGGGTGGCTGCACcttggagttgagagctggtc