Basic Information
VIS ID
TVIS20000076
Fusion event
HPV-chr5:p14.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Gene
L2/L1
Start
5599
Integrated sequence
TGGCGACAGCTTATTTTTTTATTTACGAAGGGAACAAATGTTTGTTAGACATTTATTTAATAGGGCTGGTACTGTTGGTGAAAATGTACCAGACGATTTA| |TACATTAAAGGCTCTGGGTCTACTGCAAATTTAGCCAGTTCAAATTATTTTCCTACACCTAGTGGTTCTATGGTTACCTCTGATGCCCAAATATTCAATA
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
25871329/25871220 (Hg38)
End
25871329/25871220 (Hg38)
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/8715228; hsa-mir-103a-1/Downstream/6064882;
Nearest TSS
ENST00000502646/Upstream/425295; ENST00000514255/Downstream/528599;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/680216, chr5-CpG: 29/Downstream/38013
Upstream sequence
ttGAACCATTACACATTTCATATTGAAAGTGAAGAACTGCTGAACGTAAGACATTTTACgacattggttttagtggctgggcattaaacaacgaggaaat
Downstream sequence
tttgattagagagtttagtttattttcattcaatctaattattgttaagtaaggacttattcctgccattttgttatttattttctgttttaagccttct
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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