VISDB Viral Integration Site DataBase

VIS ID

TVIS20000078

Fusion event

HPV-TMEM41B integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Gene

L1

Start

5761

Integrated sequence

TGGTTCTATGGTTACCTCTGATGCCCAAATATTCAATAAACCTTATTGGTTACAACGAGCACAGGGCCACAATAATGGCATTTGTTGGGGTAACCAACTA| |TTTGTTACTGTTGTTGATACTACACGCAGTACAAATATGTCATTATGTGCTGCCATATCTACTTCAGAAACTACATATAAAAATACTAACTTTAAGGAGT

Chromosome

chr11

Cytoband

p15.4

Reference genome

Start

End

9331203/9309656 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-3940-3p ; hsa-mir-6771-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-3190-3p ; hsa-mir-4253 ; hsa-mir-6862-5p ; hsa-mir-3945 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6134 ; hsa-mir-4795-5p ; hsa-mir-1305 ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-549a ; hsa-mir-5003-3p ; hsa-mir-548l ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-24-3p ; hsa-mir-4755-3p ; hsa-mir-1238-5p ; hsa-mir-1270 ; hsa-mir-153-5p ; hsa-mir-3174 ; hsa-mir-3910 ; hsa-mir-4327 ; hsa-mir-4459 ; hsa-mir-4481 ; hsa-mir-455-3p ; hsa-mir-4633-3p ; hsa-mir-4683 ; hsa-mir-4745-5p ; hsa-mir-4758-5p ; hsa-mir-548an ; hsa-mir-620 ; hsa-mir-6499-3p ; hsa-mir-6500-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6826-5p ; hsa-mir-6840-3p ; hsa-mir-6874-5p ; hsa-mir-6880-5p ; hsa-mir-1288-5p ; hsa-mir-450a-1-3p ; hsa-mir-4768-3p ; hsa-mir-6888-5p ; hsa-mir-7112-5p

Nearest miRNA

hsa-mir-210/Upstream/219277; hsa-let-7a-2/Downstream/1198614;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/44112, chr11-CpG: 80/Downstream/4527

Upstream sequence

CGGAGCATTTTGATACCAGAAGGGAAAGCTTCATTCTCCTTGTTGTTGGTTGTTTTTTCCTTTGCTCTTTCCCCCTTCCATCTCTGACTTAAGCAAAAGA

Downstream sequence

cggagcttgcagtgagctgagattgtgccactgcactccagcctgggcgacaaagctagactcggtctcaaaataaaaataaaagtgaaaataaatgctg