Basic Information
VIS ID
TVIS20000079
Fusion event
HPV-chr8:q24.21 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
LCR
Start
7877
Integrated sequence
TGCAAGTGTGACTCTACGCTTCGGTTGTGCGTACAAAGCACACACGTAGACATTCGTACTTTGGAAGACCTGTTAATGGGCACACTAGGAATTGTGTGCC| |CCATCTGTTCTCAGAAACCATAATCTACC
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128579990/127567745 (Hg38)
End
128579990/127567745 (Hg38)
Nearest miRNA
hsa-mir-12123/Upstream/2745687; hsa-mir-10400/Downstream/228217;
Nearest TSS
ENST00000518652/Upstream/85606; ENST00000641252/Downstream/166222;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/251852, chr8-CpG: 17/Downstream/166259
Upstream sequence
AGAACCACTGTAAACAACTCAGATTTTTGGAGAAAACAGTGAAGAAGCTTTAGATCAGCAAAATAGTCGACACATGGTCCATTGGTATCTTTCTTTTTTT
Downstream sequence
TCCTAGAGGAAATGATAAAGGTCTCTCGTCTGGGCCTGTGTCTCCATTCTTTCTCCCCCTCCCACCCTGAAAAGGCATATACAGTGTGCTACCTTCTCGC
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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