PVT1 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20000080
Fusion event
HPV-PVT1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E6
Start
379
Integrated sequence
CCACTTAGTGATATTAGTGGATGTGTAGACAATAATATTAGTCCTAGATTAAAAGCTATATGTATAGAAAAACAAAGTAGAGCTGCAAAAAGGAGATTAT| |TTGAAAGCGAAGACAGCGGGTATGGCAATACTGAAGTGGAAACTCAGCAGATGTTACAGGTAGAAGGGCGCCATGAGACTGAAACACCATGTAGTCAGTA
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
129056613/128044367 (Hg38)
End
129056613/128044367 (Hg38)
Location type
Intronic
Target gene
PVT1
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1204/Upstream/35411; hsa-mir-10400/Downstream/4785;
Nearest TSS
ENST00000518652/Upstream/34709; ENST00000616386/Downstream/25793;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/194389, chr8-CpG: 122/Downstream/1894759
Nearest cancer related gene
PVT1(OG, No orient, 0)
Upstream sequence
TAAACAACTCAGATTTTTGGAGAAAACAGTGAAGAAGCTTTAGATCAGCAAAATAGTCGACACATGGTCCATTGGTATCTTTCTTTTTTTTAATGTGAAT
Downstream sequence
aagtgctttattccctggaaaatggtaagtgcctactaaatatttgttaaatgcataagtCTCTATTTTGGAGATGACCTCCACACCCAGCctcaggcac
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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