VISDB Viral Integration Site DataBase

VIS ID

TVIS20000082

Fusion event

HPV-FGFR3 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E1

Start

1362

Integrated sequence

TATGAGTCAATGGATAAAATATAGATGTGATAGGGTAGATGATGGAGGTGATTGGAAGCAAATTGTTATGTTTTTAAGGTATCAAGGTGTAGAGTTTATG| |TCATTTTTAACTGCATTAAAAAGATTTTTGCAAGGCATACCTAAAAAAAATTGCATATTACTATATGGTGCAGCTAACACAGGTAAATCATTATTTGGTA

Chromosome

chr4

Cytoband

p16.3

Reference genome

Start

End

1806549/1804822 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-152-3p ; hsa-mir-425-5p ; hsa-mir-8485 ; hsa-mir-4764-5p ; hsa-mir-8064 ; hsa-mir-6796-3p

Nearest miRNA

hsa-mir-571/Upstream/1454570; hsa-mir-12113/Downstream/181562;

Nearest TSS

Nearest CpG islands

chr4-CpG: 16/Target, None/Upstream, None/Downstream

Nearest cancer related gene

FGFR3(OG, No orient, 0)

Upstream sequence

TTGACAAATGCCATCGGATGGAGCTTCTCTAACAGCCCATGGGGACACAGACCAAGAGATCATGGCTGGTATCTGTCAGCTTAGGAAGCATGCCTGCCTG

Downstream sequence

GGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTCC