Basic Information
VIS ID
TVIS20000084
Fusion event
HPV-chr2:p16.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
L2/L1
Start
4963
Integrated sequence
CACAAACATATATTATCATGCAGGAACATCCAGACTACTTGCAGTTGGACATCCCTATTTTCCTATTAAAAAACCTAACAATAACAAAATATTAGTTCCT| |AAAGTATCAGGATTACAATACAGGGTATTTAGAATACATTTACCTGACCCCAATAAGTTTGGTTTTCCTGACACCTCATTTTATAATCCAGATACACAGC
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
59909510/59682375 (Hg38)
End
59909510/59682375 (Hg38)
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1301/Upstream/3681580; hsa-mir-10b/Downstream/704987;
Nearest TSS
ENST00000437798/Upstream/247162; ENST00000444873/Downstream/50956;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1253398, chr2-CpG: 103/Downstream/778312
Upstream sequence
tgcattcaggggggctcagcaccctgagctgctgtcctccttgaagtgtttgtcagtgacagaaactatgaggctgaaaaggtgagcagaAAGCAATGGC
Downstream sequence
tctatttcttgactcttcattctatgccactgatctttttgtctgtctctacaccagcgatcagcaaatgatggccacaggtgaagtctggcctactgtc
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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