VISDB Viral Integration Site DataBase

VIS ID

TVIS20000085

Fusion event

HPV-DPP6 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Gene

L2/L1

Start

5609

Integrated sequence

TTATTTTTTTATTTACGAAGGGAACAAATGTTTGTTAGACATTTATTTAATAGGGCTGGTACTGTTGGTGAAAATGTACCAGACGATTTATACATTAAAG| |GCTCTGGGTCTACTGCAAATTTAGCCAGTTCAAATTATTTTCCTACACCTAGTGGTTCTATGGTTACCTCTGATGCCCAAATATTCAATAAACCTTATTG

Chromosome

chr7

Cytoband

q36.2

Reference genome

Start

End

154556784/154765074 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-4668-5p ; hsa-mir-3153 ; hsa-mir-513b-3p ; hsa-mir-1276 ; hsa-mir-497-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-511-5p ; hsa-mir-6830-3p

Nearest miRNA

hsa-mir-10399/Upstream/3331435; hsa-mir-153-2/Downstream/2809262;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/14436, chr7-CpG: 59/Downstream/28898

Upstream sequence

taagagctccagtgttaggtgcctatgtgtttgggatcgtgatattttcctcttgggcaaggccttttaccattatctaatgtccttctttgtctctttt

Downstream sequence

caaaccacagcacacatatgaatgagatcattcggcattcgtctttctgtttctggtttatttcacttagcacaagtcctccaggtttatctactatgtt