Basic Information
VIS ID
TVIS20000088
Fusion event
HPV-SLC17A6 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E6
Start
164
Integrated sequence
AGGCTGTAGTGGAAAAAAAAACAGGGGATGCTATATCAGATGACGAGAACGAAAATGACAGTGATACAGGTGAAGATTTGGTAGATTTTATAGTAAATGA| |TAATGATTATTTAACACAGGCAGAAACAGAGACAGCACATGCGTTGTTTACTGCACAGGAAGCAAAACAACATAGAGATGCAGTACAGGTTCTAAAACGA
Host Sequence
Chromosome
chr11
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
22388589/22367043 (Hg38)
End
22388589/22367043 (Hg38)
Location type
Intronic
Target gene
SLC17A6
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-210/Upstream/2606960; hsa-let-7a-2/Downstream/1052062;
Nearest TSS
ENST00000527297/Upstream/4749; ENST00000531858/Downstream/80333;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/25212, chr11-CpG: 20/Downstream/65711
Upstream sequence
TGTACTTGTTTCTCTGTTGTAAGAATAGGCATTAACACAAAGGAGGCGTCTCGGGAGAGGATTAGGTTCCATCCTTTACGTGTTTAAAAAAAAGCATAAA
Downstream sequence
atgcatgcgcatgcacacacacacacacgcgcgcgcacacacacacacacacacacacacacacaAATCCCTTTTTATAAAAAATGTTTGAGAAACAAAA
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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