VISDB Viral Integration Site DataBase

VIS ID

TVIS20000090

Fusion event

HPV-CAPG integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E2

Start

3717

Integrated sequence

TACAGATACACTTGCTCCTGTAAGACCCCCTTTAACAGTAGATCCTGTGGGCCCTTCTGATCCTTCTATAGTTTCTTTAGTGGAAGAAACTAGTTTTATT| |GATGCTGGTGCACCAACATCTGTACCTTCCATTCCCCCAGATGTATCAGGATTTAGTATTACTACTTCAACTGATACCACACCTGCTATATTAGATATTA

Chromosome

chr2

Cytoband

p11.2

Reference genome

Start

End

85639289/85412166 (Hg38)

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2L

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-1-3p ; hsa-mir-34a-5p

Nearest miRNA

hsa-mir-1285-2/Upstream/5545583; hsa-mir-10b/Downstream/371434;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/57326, chr2-CpG: 29/Downstream/1680

Nearest cancer related gene

CAPG(TSG, No orient, 0)

Upstream sequence

caaaggtggtgagggttgggggggcggtccagtttataggtagattttaaaattttctggttgacaattggttgagcttatctagacctgggatcaacag

Downstream sequence

GCCTGTAGCTAGCATCCAAGTGTCTCCATGGCCAAACTGCCAGGCTTAAAAATAGGGTAATATGggccgggcgcggtggctcacgcctgtaatcccagca