Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20000091
Fusion event
HPV-NFIB integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Region type
E6
Start
384
Integrated sequence
TAGTGATATTAGTGGATGTGTAGACAATAATATTAGTCCTAGATTAAAAGCTATATGTATAGAAAAACAAAGTAGAGCTGCAAAAAGGAGATTATTTGAA| |AGCGAAGACAGCGGGTATGGCAATACTGAAGTGGAAACTCAGCAGATGTTACAGGTAGAAGGGCGCCATGAGACTGAAACACCATGTAGTCAGTATAGTG
Host Sequence
Chromosome
chr9
Cytoband
p22.3
Reference genome
Start
End
14288872/14288873 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-130b-3p ; hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-92a-3p ; hsa-mir-548c-3p ; hsa-mir-4668-3p ; hsa-mir-1277-5p ; hsa-mir-590-3p ; hsa-mir-19a-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-5011-5p ; hsa-mir-3714 ; hsa-mir-548aw ; hsa-mir-190a-3p ; hsa-mir-335-3p ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-4517 ; hsa-mir-605-3p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-20a-5p ; hsa-mir-6857-5p ; hsa-mir-491-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-4650-3p ; hsa-mir-4450 ; hsa-mir-3134 ; hsa-mir-6134 ; hsa-mir-1197 ; hsa-mir-6757-3p ; hsa-mir-3924 ; hsa-mir-656-3p ; hsa-mir-4775 ; hsa-mir-512-3p ; hsa-mir-4803 ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302e ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-3912-5p ; hsa-mir-6748-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-605-5p ; hsa-mir-339-5p ; hsa-mir-6876-3p ; hsa-mir-626 ; hsa-mir-6773-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-1228-3p ; hsa-mir-3185 ; hsa-mir-1246 ; hsa-mir-129-5p ; hsa-mir-3672 ; hsa-mir-4524a-3p ; hsa-mir-6864-3p ; hsa-mir-8055 ; hsa-mir-431-5p ; hsa-mir-5691 ; hsa-mir-624-3p ; hsa-mir-6805-3p
Nearest miRNA
hsa-mir-101-2/Upstream/8280969; hsa-let-7a-1/Downstream/4284433;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/965522, chr9-CpG: 242/Downstream/24080
Nearest cancer related gene
NFIB(OG, No orient, 0)
Upstream sequence
TCTTGTCCACACTGCAGGGACTGAAAGGGGAAGTGGAGGCTGGAGAAGGCACTAGAAGAGCAGTTTCTACAGAATGTTGGAGGCAGAGCAGCTTGCAGGG
Downstream sequence
cctgaaaagttctactattgacatagtagaattactatgtcaatgtactgcttatttaaccaatttcttattgtttaaattttacattgtttccagtttt
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.