VISDB Viral Integration Site DataBase

VIS ID

TVIS20000093

Fusion event

HPV-MACROD2 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E7

Start

858

Integrated sequence

ACTATTACAACAATATTGTTTATATTTACACATTCAAAGTTTAGCATGTTCATGGGGAATGGTTGTGTTACTATTAGTAAGATATAAATGTGGAAAAAAT| |AGAGAAACAATTGAAAAATTGCTGTCTAAACTATTATGTGTGTCTCCAATGTGTATGATGATAGAGCCTCCAAAATTGCGTAGTACAGCAGCAGCATTAT

Chromosome

chr20

Cytoband

p12.1

Reference genome

Start

End

15070638/15089992 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/4440297; hsa-mir-1-1/Downstream/3380623;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/1093570, chr20-CpG: 50/Downstream/1483199

Upstream sequence

acggttctggacactagaagtgtgagatcacagtgccagcaaggttggcttctctctccctttctctctctctctcttttttttttttttaggtagggtc

Downstream sequence

GCTACGTAGGATCAGCTTTCAGAGGAGTAGTTTAGATCAGTGTGTGCTGAGATGTTTGAGAGAGAATAAAAATCACACAGGATTTGGTCTGTTGCACTGC