VISDB Viral Integration Site DataBase

VIS ID

TVIS20000095

Fusion event

HPV-chr20:p12.1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E1

Start

1975

Integrated sequence

GAGGACAAGGAAAACGATGGAGACTCTTTGCCAACGTTTAAATGTGTGTCAGGACAAAATACTAACACATTATGAAAATGATAGTACAGACCTACGTGAC| |CATATAGACTATTGGAAACACATGCGCCTAGAATGTGCTATTTATTACAAGGCCAGAGAAATGGGATTTAAACATATTAACCACCAGGTGGTGCCAACAC

Chromosome

chr20

Cytoband

p12.1

Reference genome

Start

End

14869191/14888545 (Hg38)

Location type

Intronic

Target gene

MACROD2 ; MACROD2-AS1

miRNAs that regulate target gene

hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/4238850; hsa-mir-1-1/Downstream/3582070;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/892123, chr20-CpG: 50/Downstream/1684646

Upstream sequence

GCTGTGGGGGGGCAATGGGGAAGATGAGTCAGATTCATCACTATGTCCCAGCACCTCTTACCACATCCCATGGCCTCTAGTGAAGCAGGAGAAGGATTGT

Downstream sequence

CCCTCTGTTGTAACTACATGGCCAGAGGGACATGCAACCCaattaaataaaattaattttaaGCACACATCCTGATTTGGAGAAGCATTTGGACAATAAC