VISDB Viral Integration Site DataBase

VIS ID

TVIS20000103

Fusion event

HPV-TP63 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E1

Start

1661

Integrated sequence

TAGATGATGCTACAGTGCCCTGTTGGAACTACATAGATGACAATTTAAGAAATGCATTGGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGACCATT| |GGTACAACTAAAATGCCCTCCATTATTAATTACATCTAACATTAATGCTGGTACAGATTCTAGGTGGCCTTATTTACATAATAGATTGGTGGTGTTTACA

Chromosome

chr3

Cytoband

q28

Reference genome

Start

End

189584107/189866318 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-21-5p ; hsa-mir-124-3p ; hsa-mir-301b-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-4477b ; hsa-mir-1178-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428

Nearest miRNA

hsa-let-7g/Upstream/36309; hsa-mir-3137/Downstream/5268188;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/918555, chr3-CpG: 99/Downstream/253973

Nearest cancer related gene

TP63(TSG, No orient, 0)

Upstream sequence

CTATGCCACCCACTAAGGACCAGAAAAGCCCCTGGAAGTGTTTATTCCATTTCCTTGGGGCTCATCTCCTGAATTCTTTTAGATTTTCCTAAATTATACT

Downstream sequence

AAATTAATTTGCTTATTTCCCTTTCATTTTCCAGGAAGCTGGCAAAATTTCCTCCACGATGAGGTCAGAGATGTAGTTATAGAGTTCCATAAAGCTTGAA