VISDB Viral Integration Site DataBase

VIS ID

TVIS20000106

Fusion event

HPV-DIAPH2 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E1

Start

1356

Integrated sequence

AATGAGTATGAGTCAATGGATAAAATATAGATGTGATAGGGTAGATGATGGAGGTGATTGGAAGCAAATTGTTATGTTTTTAAGGTATCAAGGTGTAGAG| |TTTATGTCATTTTTAACTGCATTAAAAAGATTTTTGCAAGGCATACCTAAAAAAAATTGCATATTACTATATGGTGCAGCTAACACAGGTAAATCATTAT

Chromosome

chrX

Cytoband

q21.33

Reference genome

Start

End

96471972/97216973 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p

Nearest miRNA

hsa-let-7f-2/Upstream/2153747; hsa-mir-105-1/Downstream/9422841;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/531606, chrX-CpG: 23/Downstream/2722363

Upstream sequence

GAGTAATATTTAGATGGTAACCCCTGCATGATCCATCCACAGGAATTCATTTACTTCTCTTTCTTGCACCATTCAGGCAGCAGTGAAACCTTTCTCTACA

Downstream sequence

TTTCTGTCACATAGTAAACACTTAGTACTATGTATGGAATTGAATTTAATAATATTAATTGGTTTAGCATGAAAAAAATTATGCTATAGTGTGAGTTAAA