Basic Information
VIS ID
TVIS20000107
Fusion event
HPV-chr6:q15 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E1
Start
1728
Integrated sequence
TTTAGTTTCTATGGATGTAAAGCATAGACCATTGGTACAACTAAAATGCCCTCCATTATTAATTACATCTAACATTAATGCTGGTACAGATTCTAGGTGG| |CCTTATTTACATAATAGATTGGTGGTGTTTACATTTCCTAATGAGTTTCCATTTGACGAAAACGGAAATCCAGTGTATGAGCTTAATGATAAGAACTGGA
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
93013206/92303488 (Hg38)
End
93013206/92303488 (Hg38)
Fragile sites / regions
FRA6G
Nearest miRNA
hsa-mir-10398/Upstream/781751; hsa-mir-1202/Downstream/5721043;
Nearest TSS
ENST00000381078/Upstream/613060; ENST00000452624/Downstream/85339;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1691988, chr6-CpG: 92/Downstream/1113066
Upstream sequence
cccaggcaggatggctcgaaatttcatcatgctgcttagaacggtgtgcaatttaaaacttagaaactgtttatttctggaattttccatttaatattta
Downstream sequence
gaagacaggctgtttggaaagacacagtcagagaagacaaaagaaaaaacaataaaaaatgaggcacgcctacaggatctaagaaacagcctgaaaatgg
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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