VISDB Viral Integration Site DataBase

VIS ID

TVIS20000110

Fusion event

HPV-CNTNAP2 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E1

Start

2189

Integrated sequence

AATAAAGCATTACAAGCAATTGAACTGCAACTAACGTTAGAAACAATATATAACTCACAATATAGTAATGAAAAGTGGACATTACAAGACGTTAGCCTTG| |AAGTGTATTTAACTGCACCAACAGGATGTATAAAAAAACATGGATATACAGTGGAAGTGCAGTTTGATGGAGACATATGCAATACAATGCATTATACAAA

Chromosome

chr7

Cytoband

q35

Reference genome

Start

End

147585823/147888731 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u

Nearest miRNA

hsa-mir-10399/Upstream/510610; hsa-mir-153-2/Downstream/3349690;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/1771739, chr7-CpG: 33/Downstream/450671

Nearest cancer related gene

CNTNAP2(TSG, No orient, 0)

Upstream sequence

gaaagaaaacactgttgttagttgcagatgtaatgaatttcctacataaaaaatGTAggctttcaggcaaagacggcaaattgaacgcatgaatctaatt

Downstream sequence

agaaaataaccattgaccttgaatatgccacccagaaaaaaacacatatataaagtctaaataaagactttttaggacaaaATAATGATAACATACTACC