Basic Information
VIS ID
TVIS20000111
Fusion event
HPV-chr7:q31.31 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E1
Start
2370
Integrated sequence
ATACAATGCATTATACAAACTGGACACATATATATATTTGTGAAGAAGCATCAGTAACTGTGGTAGAGGGTCAAGTTGACTATTATGGTTTATATTATGT| |TCATGAAGGAATACGAACATATTTTGTGCAGTTTAAAGATGATGCAGAAAAATATAGTAAAAATAAAGTATGGGAAGTTCATGCGGGTGGTCAGGTAATA
Host Sequence
Chromosome
chr7
Cytoband
q31.31
Reference genome
GRCh37/hg19
Start
117973872/118333818 (Hg38)
End
117973872/118333818 (Hg38)
Nearest miRNA
hsa-mir-10525/Upstream/1313499; hsa-mir-10399/Downstream/8724270;
Nearest TSS
ENST00000635602/Upstream/93843; ENST00000421825/Downstream/1573557;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/119151, chr7-CpG: 93/Downstream/1938968
Upstream sequence
tatgcacatgcacgtaagttcaaggaaaaagggctggaaggttaacacctgtcaatggcgcatatgcccggagggaagatggggtggtctttgtcttatc
Downstream sequence
ACCCTCATAAGTTTATAATTGAAAAATAATGCAGATGAGTGATTCTTTTAGAAGTAGATTCTAGTGAACAAATGTTGGGATCATTTGACATCGAGGCTGA
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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