Basic Information
VIS ID
TVIS20000112
Fusion event
HPV-chr1:p21.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
2816
Integrated sequence
AAAGGACGGATTAACTGTAATAGTAACACTACACCCATAGTACATTTAAAAGGTGATGCTAATACTTTAAAATGTTTAAGATATAGATTTAAAAAGCATT| |GTACATTGTATACTGCAGTGTCGTCTACATGGCATTGGACAGGACATAATGTAAAACATAAAAGTGCAATTGTTACACTTACATATGATAGTGAATGGCA
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
103005957/102540401 (Hg38)
End
103005957/102540401 (Hg38)
Nearest miRNA
hsa-mir-101-1/Upstream/2259093; hsa-mir-11399/Downstream/5356822;
Nearest TSS
ENST00000473358/Upstream/150771; ENST00000414923/Downstream/313441;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1303212, chr1-CpG: 85/Downstream/985069
Upstream sequence
AATTTACCattaaaaaattttagaataaatctaataaaatgaataaaatagttataaaaatCATACAAAATCATGATGAACATTTGATATAGAGGGTTTA
Downstream sequence
Cacagcaaatgagatgacgccgtagtgtcacccggctttggggaatcatgtgcatagtggaagtcagggtaaggaccaagtgaacagagagtgaaggagg
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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