Basic Information
VIS ID
TVIS20000113
Fusion event
HPV-chr2:q32.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
2991
Integrated sequence
CACTTACATATGATAGTGAATGGCAACGTGACCAATTTTTGTCTCAAGTTAAAATACCAAAAACTATTACAGTGTCTACTGGATTTATGTCTATATGACA| |AATCTTGATACTGCATCCACAACATTACTGGCGTGCTTTTTGCTTTGCTTTTGTGTGCTTTTGTGTGTCTGCCTATTAATACGTCCGCTGCTTTTGTCTG
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
188223631/187358904 (Hg38)
End
188223631/187358904 (Hg38)
Location type
Intronic
Target gene
CALCRL ; LOC105373786
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-10b/Upstream/2979860; hsa-mir-1244-1/Downstream/938588;
Nearest TSS
ENST00000437798/Upstream/355630; ENST00000428329/Downstream/89242;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/509562, chr2-CpG: 106/Downstream/932785
Upstream sequence
caaaggtggtgagggttgggggggcggtccagtttataggtagattttaaaattttctggttgacaattggttgagcttatctagacctgggatcaacag
Downstream sequence
cagatatgataccttcactaaacgctattcatttaagcactgtgaacatgcatgtccatctgtgtccactgggaccctgaaggatacCATAGGCCAGATG
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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