Basic Information
VIS ID
TVIS20000114
Fusion event
HPV-chr5:p13.3 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
3331
Integrated sequence
ACATAATGTATATGTACATAATGTAATTGTTACATATAATTGTTGTATACCATAACTTACTATTTTTTCTTTTTTATTTTCATATATAATTTTTTTTTTT| |GTTTGTTTGTTTGTTTTTTAATAAACTGTTATTACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAA
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
31137921/31137814 (Hg38)
End
31137921/31137814 (Hg38)
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/13981822; hsa-mir-103a-1/Downstream/798288;
Nearest TSS
ENST00000502646/Upstream/1741833; ENST00000506396/Downstream/55936;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2209284, chr5-CpG: 37/Downstream/56031
Upstream sequence
ATCCGTTTCTTAAAGGACATTCACACTTATGAAGTGTTTAGGGCAAAGCAAAAAGGAGGAAGGTGAGGGAAATTCCTGATGACTTTACTGATGTTAAAAT
Downstream sequence
AGGAGATAATGATTTTAAGCAAGAACATTGAAATAAAATATCCCATAAGGTTCTGAGTCAGCTCATGTTCATTTTCTTGTTAATTAGAAACAGTGAGGAC
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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