Basic Information
VIS ID
TVIS20000115
Fusion event
HPV-chr2:p21 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2/E4
Start
3402
Integrated sequence
TTTTATTTTCATATATAATTTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATTACTTAACAATGCGACACAAACGTTCTGCAAAACGCACA| |AAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATC
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
42298926/42071786 (Hg38)
End
42298926/42071786 (Hg38)
Nearest miRNA
hsa-mir-1301/Upstream/6600300; hsa-mir-10b/Downstream/5305889;
Nearest TSS
ENST00000437798/Upstream/16829; ENST00000482660/Downstream/97564;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/22920, chr2-CpG: 47/Downstream/29563
Upstream sequence
cctccctggccatgtggagctgtaagtccaataaacctctttcttttgtaaattgcccagtctcaggtatgtctttatcagcagcgtgaaaatggactaa
Downstream sequence
GAGAGCTGGGAAATGTGTGGCTCTAGTAGGCCGCTCCTGAAGATGAGCAGAAATTCAGTTATTCCAGCCTTCTCCAAATCCAGAAGAAAGTATCCAAAGC
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
Curate