Basic Information
VIS ID
TVIS20000117
Fusion event
HPV-chr2:q37.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
L2
Start
4879
Integrated sequence
TCTTTGGCTGCCTAGTGAGGCCACTGTCTACTTGCCTCCTGTCCCAGTATCTAAGGTTGTAAGCACGGATGAATATGTTGCACGCACAAACATATATTAT| |CATGCAGGAACATCCAGACTACTTGCAGTTGGACATCCCTATTTTCCTATTAAAAAACCTAACAATAACAAAATATTAGTTCCTAAAGTATCAGGATTAC
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
231434760/230570045 (Hg38)
End
231434760/230570045 (Hg38)
Nearest miRNA
hsa-mir-10b/Upstream/3097858; hsa-mir-1244-1/Downstream/792663;
Nearest TSS
ENST00000437798/Upstream/32403; ENST00000484398/Downstream/9888;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/501211, chr2-CpG: 125/Downstream/142549
Nearby gene
LOC112268431(+1850) ;
Upstream sequence
gcagactgcattaaaagatcaagacccaattatatgctatttataagaaatatactgtaagtataagaaaaaccaaatagattaaaataaaatgatagaa
Downstream sequence
ctccaggtgagcctcaaccccacctccaacacataaatgtattcaccaattcagaagctccctgaaccctgttgttcaggggtttttatcaaggtttcat
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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