Basic Information
VIS ID
TVIS20000121
Fusion event
HPV-chr2:p21 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.4
Region type
E2
Start
3721
Integrated sequence
GATACACTTGCTCCTGTAAGACCCCCTTTAACAGTAGATCCTGTGGGCCCTTCTGATCCTTCTATAGTTTCTTTAGTGGAAGAAACTAGTTTTATTGATG| |CTGGTGCACCAACATCTGTACCTTCCATTCCCCCAGATGTATCAGGATTTAGTATTACTACTTCAACTGATACCACACCTGCTATATTAGATATTAATAA
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
45180348/44953209 (Hg38)
End
45180348/44953209 (Hg38)
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1301/Upstream/9481723; hsa-mir-10b/Downstream/2424466;
Nearest TSS
ENST00000437798/Upstream/11311; ENST00000425325/Downstream/1455;
Nearest CpG islands
chr2-CpG: 94/Target, None/Upstream, None/Downstream
Nearby gene
SIX3(-7132) ;
Upstream sequence
CATGACCACTTCTGCTGCCATGCCTCAGTTTCTCTATTTGTAAAGCTATATTTATACAGGTCAATTAAGGATGCTGCTTAAGGATGTTGGGATAATATTT
Downstream sequence
AGCGGGGATTTCAGGGGCCTCCGCTCCCACAGCGGACCGGCCTCCGCTTAAACCACCAGCACTTCCCAGTGGGCCTGGGAATCGAGGATGTGAAGTGTGT
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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