VISDB Viral Integration Site DataBase

VIS ID

TVIS20000123

Fusion event

HPV-DNM2 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E6

Start

340

Integrated sequence

GATGCAGTACAGGTTCTAAAACGAAAGTATTTGGGTAGTCCACTTAGTGATATTAGTGGATGTGTAGACAATAATATTAGTCCTAGATTAAAAGCTATAT| |GTATAGAAAAACAAAGTAGAGCTGCAAAAAGGAGATTATTTGAAAGCGAAGACAGCGGGTATGGCAATACTGAAGTGGAAACTCAGCAGATGTTACAGGT

Chromosome

chr19

Cytoband

p13.2

Reference genome

Start

End

10902225/10791549 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-130a-3p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-mir-6875-5p ; hsa-mir-6809-5p ; hsa-mir-765 ; hsa-mir-711 ; hsa-mir-4784 ; hsa-mir-4708-3p ; hsa-mir-3150b-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4761-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125

Nearest miRNA

hsa-mir-1181/Upstream/11214; hsa-let-7e/Downstream/25877;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/72885, chr19-CpG: 70/Downstream/44291

Upstream sequence

CCTTGGACACTTTCCAGCATTGCGGGGAACCCTCAGAACCTGCCTTTCTGTGATCCCCCACCTTCCTTTGTTCCTCCCCAGACCTGGCCCTTCTCTGTGC

Downstream sequence

GCCGGTCACAATTGTCCAGAATGCTCTGATTGTGCAGCGTGGGTTGGGCCTGTAAATCACCTCCAGGGCCCCCAGGAGGCTGGTGCCCAGGTGTGCTTTG