VISDB Viral Integration Site DataBase

VIS ID

TVIS20000125

Fusion event

HPV-NELFE integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Region type

E2

Start

3800

Integrated sequence

AAGAAACTAGTTTTATTGATGCTGGTGCACCAACATCTGTACCTTCCATTCCCCCAGATGTATCAGGATTTAGTATTACTACTTCAACTGATACCACACC| |TGCTATATTAGATATTAATAATACTGTTACTACTGTTACTACACATAATAATCCCACTTTCACTGACCCATCTGTATTGCAGCCTCCAACACCTGCAGAA

Chromosome

chr6

Cytoband

p21.33

Reference genome

Start

End

31923670/31955893 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-877-5p ; hsa-mir-628-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-124-5p ; hsa-mir-3683 ; hsa-mir-1273c ; hsa-mir-488-5p ; hsa-mir-501-5p

Nearest miRNA

hsa-mir-3143/Upstream/254802; hsa-mir-10398/Downstream/946;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/53585, chr6-CpG: 52/Downstream/2819

Upstream sequence

CTTAAAAATGTGACACGCTTCCAAAATCTCATATAGAATGTTAGAGATCTGCAAACACCCCAGTCTCTCTGGACCCCTGCACCAAGAGCGATTACTTGAT

Downstream sequence

tcagtaactgggactataagtgtgcaccaccacattctgctaattttttttttttttgagacggagtctcgctgtcacccaggctggagtgcagtggcac