Basic Information
VIS ID
TVIS20000129
Fusion event
HPV-chr17:q23.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
NC_001526.2
Region type
E2
Start
3782
Integrated sequence
GTGATGCTA ATACTTTAAAATGTTTAAGATATAGATTTAAAAAGCATTGTACATTGTATACTGCAGTGTCGTCTACATG GCATTGGACAGGACATAAT| |GTAAAACATAAAAGTGCAATTGTTACACTTACATATGATAGTGAATGGCAA CGTGACCAATTTTTGTCTCAAGTTAAAATACCAAAAACTATTACAGTG
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
57925564/59848203 (Hg38)
End
57925564/59848203 (Hg38)
Nearest miRNA
hsa-mir-10226/Upstream/6866; hsa-mir-1250/Downstream/194822;
Nearest TSS
ENST00000595228/Upstream/10252; ENST00000477179/Downstream/30559;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/140456, chr17-CpG: 73/Downstream/44478
Nearby gene
RNU6-450P(-659) ;
Upstream sequence
GTGGAACCTTTGCCAAACCTCAGAGCTGCAGCGAGCGGCTGGGCAACCTTCCTGAGGACGGCGCCCCCTCGCCCAGCTCCAAGCTCCTCCCTGTCCCCAC
Downstream sequence
agtggggcgatctccgctcactgcaggctccgcctcccgggttcaagccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccacc
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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