Basic Information
VIS ID
TVIS20000132
Fusion event
HPV-chr8:q24.21 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
NC_001526.2
Region type
E1
Start
2497
Integrated sequence
TTGTAAATTCTAAAAG CCATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTATGTTAGATGATGCTACAGTGCCCTGTTGG AACTACATAGAT| |GACAATTTAAGAAATGCATTGGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGAC CATTGGTACAACTAAAATGCCCTCCATTATTAATTACATCT
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128241548/127229303 (Hg38)
End
128241548/127229303 (Hg38)
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/2407245; hsa-mir-10400/Downstream/566659;
Nearest TSS
ENST00000518652/Upstream/149429; ENST00000642795/Downstream/15334;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/670778, chr8-CpG: 29/Downstream/86339
Upstream sequence
aagtgtgtttttatccttgcctcagccatTTCTTTTTACACATTTAATTTTTTCctctcagcttattacttttttcatatttcattgaaaaaatagatgc
Downstream sequence
catatatatTGGTTATACCTATATATGGACATATATAGGTCCACTCTTCTCATATCCACAGCTGCTATCAATATAATAAATGGGCAGTATCTGTAGTATC
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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