VISDB Viral Integration Site DataBase

VIS ID

TVIS20000136

Fusion event

HPV-ZBTB7C integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HPV

Subtype

HPV58

Reference genome

Region type

E6

Start

135

Integrated sequence

GGAGTAACCGAAAACGGTCGGGACCGAAAACGGTG TATATAAAAGATGTGAGAAACACACCACAATACTATGGCGCGCTTTGAGGATCCAACACGGCGA| |CCCTAC AAGCTACCTGATCTGTGCACGGAACTGAACACTTCACTGCAAGACATAGAAATAACCTGTGTATATTGCA AGACAGTATTGGAACTTACAGA

Chromosome

chr18

Cytoband

q21.1

Reference genome

Start

End

45758413/48232042 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p

Nearest miRNA

hsa-mir-1-2/Upstream/851477; hsa-mir-122/Downstream/438558;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/69901, chr18-CpG: 262/Downstream/176040

Nearest cancer related gene

ZBTB7C(TSG, No orient, 0)

Upstream sequence

aatggagattcatttcatctattaggagatctgtggttaggaaaggccttccatatgttaactcaacaggacttaattatacgttttactttggagcagt

Downstream sequence

cttggcaggcgtgggatccaggccagtagtgccagctgagcacagcctgccaggctgagtgggcaaaacgagcccaggaggcctgagcaaaactcaggca