Basic Information
VIS ID
TVIS20000140
Fusion event
HPV-chr20:q13.2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
NC_001357.1
Region type
E1
Start
2195
Integrated sequence
AATATGCCTTATTAGCAGACAGCAACAGCAATGC AGCTGCCTTTTTAAAAAGCAATTGCCAAGCTAAATATTTAAAAGATTGTGCCACAATGTGCAAAC| |ATTAT AGGCGAGCCCAAAAACGACAAATGAATATGTCACAGTGGATACGATTTAGATGTTCAAAAATAGATGAAG GGGGAGATTGGAGACCAATAGTG
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
53582110/54965571 (Hg38)
End
53582110/54965571 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/897086; hsa-mir-1-1/Downstream/2355931;
Nearest TSS
ENST00000382410/Upstream/410638; ENST00000608080/Downstream/443327;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/489117, chr20-CpG: 165/Downstream/1037976
Upstream sequence
ACAAATAAATCACTTCCTTTAGACTTTAACTTTCAGCTGAAGTGTCAGTTAGATATATGTTGGCTTTGATTCCTCTTATTTGCCTTCTATGTCCAAATAA
Downstream sequence
GCTGAAACAGATATATAGCACATCtgtgttagtctattcaggctgctataacaaaatatcttaaacctggtaatttataaacaacagaaacttattgctc
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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