Basic Information
VIS ID
TVIS20000142
Fusion event
HPV-chr20:q13.2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
NC_001357.1
Gene
L1
Start
5989
Integrated sequence
TCT GCATACCAATATAGAGTATTTAGGGTGCAGTTACCTGACCCAAATAAATTTGGTTTACCTGATACTAGTA TTTATAATCCTGAAACACAACGTTT| |AGTGTGGGCCTGTGCTGGAGTGGAAATTGGCCGTGGTCAGCCTTT AGGTGTTGGCCTTAGTGGGCATCCATTTTATAATAAATTAGATGACACTGAAAG
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
53590867/54974328 (Hg38)
End
53590867/54974328 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/905843; hsa-mir-1-1/Downstream/2347174;
Nearest TSS
ENST00000382410/Upstream/419395; ENST00000608080/Downstream/434570;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/497874, chr20-CpG: 165/Downstream/1029219
Upstream sequence
GACAAGGGGAGCATGTTGCCGAACAAAAATATATTAACATGTTTGGGACTAATGCACACTGATTTTCACAGAAAGTAACTGATTGATTGCAATCAAGTAT
Downstream sequence
attacaaatcaatacacggaggttgcacattggtttaggcctaaaacagctggatatcttgaagcaagggcttacaggtggtaggtagattcagagactg
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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