Basic Information
VIS ID
TVIS20000144
Fusion event
HPV-chr4:q13.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26735580
Virus Sequence
Virus name
HPV
Subtype
HPV58
Reference genome
NC_001357.1
Region type
LCR
Start
7341
Integrated sequence
TGTGTGTGTATATATATATACATCTATTGTTGTGTTTGTATGTCCTGTGTTTGTGTTTGTTGTATGATTG CATTGTATGGTATGTATGGTTGTTGTTG| |TATGTTGTATGTTACTATATTTGTTGGTATGTGGCATTAAAT AAAATATGTTTTGTGGTTCTGTGTGTTATGTGGTTGCGCCCTAGTGAGTAACAACTG
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64506104/63640386 (Hg38)
End
64506104/63640386 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/2717702; hsa-mir-1243/Downstream/2636438;
Nearest TSS
ENST00000502981/Upstream/146108; ENST00000509473/Downstream/641150;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/290520, chr4-CpG: 32/Downstream/2029089
Upstream sequence
ttgagacagactctcaggttcctggcacaagcaactgggtagaccatggtaccaattactgaactagagattacaggggtgggggacatcttgagattct
Downstream sequence
TTTCATTGCTCTTATTTCATTTTAATTCTTTTTAGTATCAACATTTAGCTGTAGTTTGATATAAAATTCTTTATCTAAAAATTTGAAAGTAGTTATTCTG
Reference
Liu, Y., et al. Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget,2016, 7(5): 5852-5864.
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